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Tapentadol, brand names Nucynta among others, is a centrally acting opi@id analgesic of the benzenoid class with a dual mode of action as an agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor. Analgesia occurs within 32 minutes of oral administration, and lasts for 4–6 hours. Wikipedia
Other names: BN-200; CG-5503; R-331333
Metabolism: Hepatic (mostly via glucuronidation but also by CYP2C9, CYP2C19, CYP2D6)
Bioavailability: 32% (oral)
Excretion: Urine and faeces (1%)
Protein binding: 20%
AHFS/Drugs.com: Monograph
Elimination half-life: 4 hours< (duration 4-6 hours)
Tapentadol is approximately two to three times more potent than tramad@l and two to three times less potent than m@rphine.
Tapentadol, brand names Nucynta among others, is a centrally acting opi@id analgesic of the benzenoid class with a dual mode of action as an agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor. Analgesia occurs within 32 minutes of oral administration, and lasts for 4–6 hours. Wikipedia
Other names: BN-200; CG-5503; R-331333
Metabolism: Hepatic (mostly via glucuronidation but also by CYP2C9, CYP2C19, CYP2D6)
Bioavailability: 32% (oral)
Excretion: Urine and faeces (1%)
Protein binding: 20%
AHFS/Drugs.com: Monograph
Elimination half-life: 4 hours< (duration 4-6 hours)
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